LKB1 (STK11) company

Innovative R&D with repurposing

CG changes the way scientific research and development is done respective to speed, efficiency, and cost effectiveness by primarily focusing on repurposing FDA approved treatments. Innovations from rare disease research have already benefitted many diseases.

About CG

Solve the problems with Polyposis, PJS, and Cancer with repurposed treatments for LKB1 master tumor suppressor gene mutation.

treatments and cures

LKB1 (STK11) pathways and function are essential for human health, longevity and homeostasis.

LKB1 (STK11) is an essential human tumor suppressor, the key upstream activator of the AMP-activated protein kinase (AMPK). AMPK is a central metabolic switch found in all eukaryotes that govern glucose and lipid metabolism in response to alterations in nutrients and intracellular energy levels. LKB1 and AMPK control cell growth in response to environmental nutrient changes. One of the major growth regulatory pathways controlled by LKB1-AMPK is the mammalian target-of-rapamycin (mTOR) pathway. mTOR is a central integrator of nutrient and growth factors that control cell growth in all eukaryotes and is deregulated in human cancers.

LKB1 (sTK11) mutation

LKB1 (STK11) must activate AMPK to turn down mTOR (growth). A loss of function and mutation in LKB1 leads to inadequate activation of AMPK and subsequently mTOR remains elevated, leading to aberrant cell growth; a known cause for many diseases including PJS, Lung Cancer, Tuberous Sclerosis, Pancreatic Cancer, Breast Cancer, Stomach Cancer, Small intestine Cancer, Cervical Cancer, Uterine Cancer, Testicular Cancer, Esophageal Cancer, Alzheimer's disease, Cowden Syndrome, Bannayan-Riley-Ruvalcaba Syndrome, Lhermitte-Duclos disease, Proteus Syndrome, Polycystic Kidney disease, Obesity & Type 2 Diabetes, Cardiac Hypertrophy, Cardiovascular disease, Proteus Syndrome.

collaboration with online communities

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